Friday, December 16, 2011

Which of the following reagents adds a methyl group by conjugate(1,4-addition) addition to an alpha,beta-unsat

The 1,4-addition (or Michael addition) is done by cuprates, therefore the right answer is (1). This said, under certain condition, Grignard reagents (2), can also work but under clic conditions, it will do a 1,2-addition. CH3Li would do a 1,2-addition and mercury acetate would not do anythin

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